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Genomic Epidemiology of ST34 Monophasic Salmonella enterica Serovar Typhimurium from Clinical Patients Article

Yujiao Mu, Ruichao Li, Pengcheng Du, Pei Zhang, Yan Li, Shenghui Cui, Séamus Fanning, Li Bai

Engineering 2022, Volume 15, Issue 8, Pages 34-44 doi: 10.1016/j.eng.2022.05.006

Abstract:

Salmonella enterica serovar 4,[5],12:i:- (S. 4,[5],12:i:-) is a monophasic variant of Salmonella enterica serovar Typhimurium that has emergedresistance (AMR) phenotypes, and population genomics of sequence type 34 (ST34) S. 4,[5],12:i:A total of 100 ST34 S. 4,[5],12:i:- isolates were studied from 2008 to 2017 and found mostlyand tet(B) (TET) inserted into the fljBA operon, was responsible for most of the monophasic

Keywords： Salmonella Typhimuriumi> monophasic variant ST34 Prevalence Phylogenetic analysis Chinese lineages

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Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Frontiers of Medicine 2023, Volume 17, Issue 3, Pages 493-502 doi: 10.1007/s11684-022-0946-x

Abstract: Anaplastic lymphoma kinase (ALKi>) is the most common fusion gene involved in non-small cell lungIn this work, we investigated whether the variant allele frequencies (VAFs) of ALKi> fusions canALKi> positive.ALKi> subclonality with crizotinib efficacy was assessed.Results suggest that the ALKi> VAF determined by hybrid capture-based NGS is probably unreliable

Keywords： ALKi> fusion next-generation sequencing fluorescence in situi> hybridization immunohistochemistry variant allele frequency intratumoral heterogeneity targeted therapy

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: To date, four mutations in the GJB6i> gene, G11R, V37E, A88V, and D50N, have been confirmed to causeWe found a novel heterozygous missense variant (c.134G>C:p.G45A) for Clouston syndrome.Our data reveal that a novel variant (c.134G>C:p.G45A) plays a likely pathogenic role in this pedigree

Keywords： Clouston syndrome whole exome sequencing GJB6i> gene novel variant unique phenotype

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Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Frontiers of Medicine 2022, Volume 16, Issue 5, Pages 808-814 doi: 10.1007/s11684-021-0878-x

Abstract: Here, we investigated five Chinese families with EB, and eight variants including a novel nonsense variant(c.47G>A, p.W16*) in LAMA3i>, a known recurrent variant (c.74C>T, p.P25L) in KRT5i>, 2 novelCOL7A1 i>were detected.Notably, this study identified a nonsense variant in LAMA3i> that causes EB within the Chinese populationand revealed that this variant resulted in a reduction in LAMA3i> mRNA and protein expression levels

Keywords： epidermolysis bullosa LAMA3i> COL7A1i> KRT5i> Chinese families

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Quantum Dot Nanobeads-Labelled Lateral Flow Immunoassay Strip for Rapid and Sensitive Detection of Salmonellai> Typhimurium Based on Strand Displacement Loop-Mediated Isothermal Amplification Article

Yuting Shang,Shuzhen Cai,Qinghua Ye,Qingping Wu,Yanna Shao,Xiaoying Qu,Xinran Xiang,Baoqing Zhou,Yu Ding,Moutong Chen,Liang Xue,Honghui Zhu,Jumei Zhang

Engineering 2022, Volume 19, Issue 12, Pages 62-70 doi: 10.1016/j.eng.2021.03.024

Abstract: combined with strand displacement loop-mediated isothermal amplification (SD-LAMP) for quantitative Salmonella Typhimurium (ST) detection.

Keywords： Salmonella Typhimurium Quantum dot nanobeads Lateral flow immunoassay strip Loop-mediated isothermal

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Salmonellai>-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum Article

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Engineering 2024, Volume 32, Issue 1, Pages 42-57 doi: 10.1016/j.eng.2023.08.001

Abstract: Constructs carrying different HA1 regions were delivered into eukaryotic cells by SalmonellaThis discovery revolutionizes influenza vaccine design and delivery; Salmonella-mediated COBRA-HA1

Keywords： COBRA Influenza A Salmonellai> Vaccine Broad spectral protection

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Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 873-882 doi: 10.1007/s11684-022-0925-2

Abstract: VNP20009, an attenuated Salmonella typhimuriumi> strain, preferentially accumulates in the hypoxicIn this study, a novel Salmonellai>-mediated targeted expression system of tumstatin (VNP-Tum5)was developed under the control of the hypoxia-induced J23100i> promoter to obtain anti-tumor efficacyhigher efficacy in inhibiting the proliferation and inducing the necrosis and apoptosis of B16F10 cells in vitroi> and in vivoi> compared with VNP (control).

Keywords： Salmonellai> VNP20009 tumstatin B16F10 melanoma apoptosis angiogenesis

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4, Pages 448-455 doi: 10.1007/s11709-014-0262-x

Abstract: Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

Keywords： JHi> classification Qi> and RMRi> classification new method

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The Potential Role of Powdery Mildew-Resistance Gene Pm40i> in Chinese Wheat-Breeding Programs inthe Post-Pm21i> Era Perspective

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Engineering 2018, Volume 4, Issue 4, Pages 500-506 doi: 10.1016/j.eng.2018.06.004

Abstract:

Powdery mildew, which is caused by Blumeria graminis f. sp. tritici (Bgt), is an important leaf disease that affects wheat yield. Powdery mildew-resistance (Pm) gene Pm21 was first transferred into wheat in the 1980s, by translocating the Heuchera villosa chromosome arm 6VS to the wheat chromosome arm 6AL (6VS·6AL). Recently, new Bgt isolates that are virulent to Pm21 have been identified in some wheat fields, indicating that wheat breeders should be aware of the risk of deploying Pm21, although pathological details regarding these virulent isolates still remain to be discovered. Pm40 was identified and mapped on the wheat chromosome arm 7BS from several wheat lines developed from the progenies of a wild cross between wheat and Thinopyrum intermedium. Pm40 offers a broad spectrum of resistance to Bgt, which suggests that it is likely to provide potentially durable resistance. Cytological methods did not detect any large alien chromosomal segment in the wheat lines carrying Pm40. Lines with Pm40 and promising agronomical traits have been released by several wheat-breeding programs in the past several years. Therefore, we believe that Pm40 will play a role in powdery mildew-resistance wheat breeding after Pm21 resistance is overcome by Bgt isolates. In addition, both Pm21 and Pm40 were derived from alien species, suggesting that the resistance genes derived from alien species are potentially more durable or effective than those identified from wheat.

Keywords： Wheat Powdery mildew Pm21i> Pm40i> Alien species Native resistance

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NiFeRuO_xi> nanosheets on Ni foam as an electrocatalyst for efficient

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11, Pages 1698-1706 doi: 10.1007/s11705-023-2334-8

Abstract: The electrocatalyst NiFeRuO_xi>/NF, comprised of NiFeRuO_xi> nanosheetsNiFeRuO_xi>/NF displays high electrocatalytic activity and stability for overall alkalineA solar-driven system containing such a bifunctional NiFeRuO_xi>/NF has an almost 100%The NiFeRuO_xi> coating around Ni foam is an anti-corrosion layer and also a critical

Keywords： NiFeRuO_xi> nanosheets Ni foam electrocatalysis overall seawater splitting solar-driven

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Presence and Antimicrobial Susceptibility of RE-cmeABCi>-Positive Campylobacteri> Isolated Article

Dejun Liu, Weiwen Liu, Xing Li, Hong Yao, Zhangqi Shen, Yang Wang, Jianzhong Shen

Engineering 2020, Volume 6, Issue 1, Pages 34-39 doi: 10.1016/j.eng.2019.10.013

Abstract:

Campylobacter spp. (C. spp.) are the leading cause of human gastroenteritis worldwide. RE-CmeABC is a newly identified resistance-enhancing multidrug efflux pump of C. spp. that confers high-level resistance to fluoroquinolones, phenicols, macrolides, and tetracyclines, all of which are critical drugs in both human and veterinary medicine. In this study, we analyzed the presence and antimicrobial susceptibility of RE-cmeABC-positive Campylobacter isolates of food-animal origin from three representative regions (Shandong, Shanghai, and Guangdong) in China over three successive years, from 2014 to 2016. A total of 1088 Campylobacter isolates (931 C. coli and 157 C. jejuni) were recovered from the RE-cmeABC screening. We detected 122 (11.2%) RE-cmeABC-positive isolates of chicken origin, including 111 (70.7%) C. jejuni and 11 (1.2%) C. coli. This multidrug efflux pump is more prevalent among C. jejuni than C. coli. The level of resistance was significantly different in 111 RE-cmeABC-positive C. jejuni versus 46 RE-cmeABC-negative C. jejuni for florfenicol, clindamycin, and erythromycin (P < 0.05), but not for ciprofloxacin (CIP), tetracycline (TET), and gentamicin. However, the isolates harboring RE-cmeABC could shift the minimum inhibitory concentration distribution to the higher range for CIP and TET. Pulsed-field gel electrophoresis (PFGE) analysis suggested that horizontal transmission might be involved in the dissemination of RE-cmeABC in Shanghai and Guangdong, while clonal expansion was predominant in Shandong. Three isolates shared the indiscriminate PFGE types of RE-cmeABC-positive C. jejuni isolates in Shanghai and Guangdong, and four isolates in Shanghai and Shandong. Our study suggests the possibility of a wide dissemination of RE-cmeABC in Campylobacter of food-animal origin, which would pose a significant threat to public health.

Keywords： RE-cmeABCi> Campylobacteri> Ciprofloxacin Florfenicol

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A highly efficient methodology for the preparation of

Yongxin Zhang, Shucheng Wang, Yaodong Huang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 3, Pages 679-686 doi: 10.1007/s11705-020-1979-9

Abstract: A convenient and highly efficient method is described for the synthesis of -methoxycarbazole derivatives, including those with sterically demanding, benzannulated, or strongly electron-donating or -withdrawing substituents. Various -methoxycarbazole derivatives were directly prepared in good-to-moderate yields by the Pd (dba) CHCl /9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene-catalyzed reactions of the corresponding dibromobiphenyl compounds and methoxya-mine. Based on this methodology, the first total synthesis of 3,3′-[oxybis(methylene)]bis(9-methoxy-9 -carbazole), an antimicrobial dimeric carbazole alkaloid previously isolated from the stem bark of , was achieved in 18% yield over seven steps from 1,2-dibromobenzene.

Keywords： Ni>-methoxyl carbazole dimeric Ni>-methoxyl carbazole alkaloid total synthesis double Ni>-arylation of methoxyamine

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Thermal and Mechanical Properties Optimization of ABi>O₄ Type EuNbO₄ By theBi>-Site Substitution of Ta Article

Lin Chen, Jing Feng

Engineering 2020, Volume 6, Issue 2, Pages 177-184 doi: 10.1016/j.eng.2019.12.006

Abstract:

Ferroelastic ABO₄ type RETaO₄ and RENbO₄ ceramics (where RE stands for rare earth) are being investigated as promising thermal barrier coatings (TBCs), and the mechanical properties of RETaO₄ have been found to be better than those of RENbO₄. In this work, B-site substitution of tantalum (Ta) is used to optimize the thermal and mechanical properties of EuNbO₄ fabricated through a solid-state reaction (SSR). The crystal structure is clarified by means of X-ray diffraction (XRD) and Raman spectroscopy; and the surface microstructure is surveyed via scanning electronic microscope (SEM). The Young's modulus and the thermal expansion coefficient (TEC) of EuNbO₄ are effectively increased; with respective maximum values of 169 GPa and 11.2×10^–6 K^–1 (at 1200 °C). The thermal conductivity is reduced to 1.52 W·K⁻¹·m⁻¹ (at 700 °C), and the thermal radiation resistance is improved. The relationship between the phonon thermal diffusivity and temperature was established in order to determine the intrinsic phonon thermal conductivity by eliminating the thermal radiation effects. The results indicate that the thermal and mechanical properties of EuNbO₄ can be effectually optimized via the B-site substitution of Ta, and that
this proposed material can be applied as a high-temperature structural ceramic in future.

Keywords： Thermal barrier coatings Rare earth niobates Substitution Thermal conductivity Thermal expansion coefficients Young’s modulus

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Traces and echoes of De Architecturai> by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

Frontiers of Mechanical Engineering 2016, Volume 11, Issue 1, Pages 3-11 doi: 10.1007/s11465-015-0359-5

Abstract: the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifai> (On Western Hydraulicsi>).Taixi Shuifai>.found that Archimedes’ screw and Ctesibius’ machine, which are included in Vitruvius’ De Architecturai> volumes, also appear in the work of Xu Guangqi.

Keywords： Vitruvius’ De Architecturai> Xu Guangqi’s Taixi Shuifai> Jesuit missionaries Italian Renaissance

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Accounting for the uncertainties in the estimation of average shear wave velocity using – correlations

Frontiers of Structural and Civil Engineering 2021, Volume 15, Issue 5, Pages 1199-1208 doi: 10.1007/s11709-021-0749-1

Abstract: Shear wave velocity ( Vi> _S) is a key parameter in such analysis, although the economyVarious Vi> _S–SPT– Ni> correlations are routinely incorporated in seismic hazardanalysis to estimate the value of Vi> _S.i> _S calculations.The scattering nature of the Vi> _S values estimated using different Vi> _{S

Keywords：

uncertainties


Vi> _S– Ni> correlations


Vi> _S30


SPT data


statistical


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Title Author Date Type Operation

Genomic Epidemiology of ST34 Monophasic Salmonella enterica Serovar Typhimurium from Clinical Patients

Yujiao Mu, Ruichao Li, Pengcheng Du, Pei Zhang, Yan Li, Shenghui Cui, Séamus Fanning, Li Bai

Journal Article

Potential unreliability of ALK variant allele frequency in the efficacy prediction of targeted therapy

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Novel variants in LAMA3 and COL7A1 and recurrent variant in KRT5 underlying epidermolysis bullosa in

Journal Article

Quantum Dot Nanobeads-Labelled Lateral Flow Immunoassay Strip for Rapid and Sensitive Detection of Salmonellai> Typhimurium Based on Strand Displacement Loop-Mediated Isothermal Amplification

Yuting Shang,Shuzhen Cai,Qinghua Ye,Qingping Wu,Yanna Shao,Xiaoying Qu,Xinran Xiang,Baoqing Zhou,Yu Ding,Moutong Chen,Liang Xue,Honghui Zhu,Jumei Zhang

Journal Article

Salmonellai>-Delivered COBRA-HA1 Antigen Derived from H1N1 Hemagglutinin Sequences Elicits Broad-Spectrum

Ram Prasad Aganja, Amal Senevirathne, Chandran Sivasankar, John Hwa Lee

Journal Article

Bacteria-mediated tumor-targeted delivery of tumstatin (54-132) significantly suppresses tumor growth in mouse model by inhibiting angiogenesis and promoting apoptosis

Journal Article

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Journal Article

The Potential Role of Powdery Mildew-Resistance Gene Pm40i> in Chinese Wheat-Breeding Programs inthe Post-Pm21i> Era

Shengwen Tang,Yuting Hu,Shengfu Zhong,Peigao Luo

Journal Article

NiFeRuO_xi> nanosheets on Ni foam as an electrocatalyst for efficient

Journal Article

Presence and Antimicrobial Susceptibility of RE-cmeABCi>-Positive Campylobacteri> Isolated

Dejun Liu, Weiwen Liu, Xing Li, Hong Yao, Zhangqi Shen, Yang Wang, Jianzhong Shen

Journal Article

A highly efficient methodology for the preparation of

Yongxin Zhang, Shucheng Wang, Yaodong Huang

Journal Article

Thermal and Mechanical Properties Optimization of ABi>O₄ Type EuNbO₄ By theBi>-Site Substitution of Ta

Lin Chen, Jing Feng

Journal Article

Traces and echoes of De Architecturai> by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th

Michela CIGOLA,Yibing FANG

Journal Article

Accounting for the uncertainties in the estimation of average shear wave velocity using – correlations

Journal Article

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